Antimalarial Activity of Some Organotin(IV) Chlorobenzoate Compounds against Plasmodium falciparum
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چکیده
منابع مشابه
Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates
Malaria remains a major cause of childhood deaths in resource-limited settings. In the absence of an effective vaccine, drugs and other interventions have played very significant roles in combating the scourge of malaria. The recent reports of resistance to artemisinin necessitate the need for new antimalarial drugs with novel mechanisms of action. Towards the development of new, affordable and...
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Developing countries, where malaria is one of the most prevalent diseases, still rely on traditional medicine as a source for the treatment of this disease. In the present study, six selected plants (Acalypha fruticosa, Azadirachta indica, Cissus rotundifolia, Echium rauwalfii, Dendrosicyos socotrana and Boswellia elongata) commonly used in Yemen by traditional healers for the treatment of mala...
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Received 10th December, 2012 Received in revised form 20th, December, 2012 Accepted 5th January, 2013 Published online 31 January, 2013 Objective: The antiplasmodial activity of pure n e e m l i m o n o i d s (azadirachtin, salannin, deacetylgedunin, gedunin, 17-h ydroxyazadiradione and deacetylnimbin) was evaluated in vitro against the chloroquine resistant and-sensitive strains of P. falcipar...
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The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
متن کاملEffect of membrane filtration of antimalarial drug solutions on in vitro activity against Plasmodium falciparum.
Antimalarial activities of chloroquine, mefloquine, amodiaquine, and quinine in vitro against Plasmodium falciparum were diminished as a consequence of membrane filtration. Filtered drug solutions gave ID(50) values up to 25-fold greater than those of non-filtered (ethanol-sterilized) drug solutions. Loss of activity by filtration was overcome by increasing the drug concentration prior to filtr...
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ژورنال
عنوان ژورنال: Mediterranean Journal of Chemistry
سال: 2020
ISSN: 2028-3997
DOI: 10.13171/mjc0200312162sh